Little Known Facts About cees dekker.
Little Known Facts About cees dekker.
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Making use of single-molecule optical and AFM imaging and drive-spectroscopy tactics, we find to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our investigation interests include:
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‘It was simply just a make any difference of finding up a e-book on cell biology and beginning to read through. I had originate from a entire world of extremely-higher vacuums, cryostats and quantum phenomena, and now I had been Performing at area temperature with molecular biology kits.
Non-equilibrium folding of person DNA molecules recaptured as much as 1000 occasions inside a strong state nanopore
De sterke polarisatie in de discussie rond schepping/evolutie en meer algemeen rond geloof/wetenschap lijkt helaas geen eind te kennen. Toch is er wel degelijk een heilzame middenweg, maar deze krijgt more than het algemeen weinig aandacht. Dit boek kan hier wellicht verandering in brengen. Wie de geschiedenis van de relatie tussen geloof en wetenschap in duikt, komt tot verrassende inzichten. De moderne mens leeft met veel stereotypen die historisch niet verantwoord blijken te zijn. Afgezaagde typeringen als ‘Vroeger dachten we dat de
SMC complexes can move physical roadblocks larger than their ring sizing, indicating a nontopological system for DNA loop extrusion
Lots of related developments followed, in which our group set up distinct transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest proof-of-theory electronic circuits.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
What if, in lieu of employing standard major-down silicon electronics, transistors may be built from The underside up using solitary organic molecules given that the switching factors? This concept, which grew to become The premise of right now’s industry of molecular electronics, very first emerged during the 1970s.
There was 1 difficulty however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up basically not such great conductors, which was instead disappointing. We Hence broadened our check out to try to discover a lot more promising molecules.
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2001, discovery of solitary-electron transistors at area temperature determined by nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular composition of DNA maintenance enzymes with AFM
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and initial power measurements over a DNA molecule in a nanopore
The biophysicist from Delft – who continues to be Probably the most cited scientists during the Netherlands For some time – will take his responsibility to add to your clarification and popularisation of his perform in the border of physics and biology extremely very seriously and on a regular basis appears in the media; Otherwise to mention his function, then about the connection involving science and his Christian faith.